Season five of Grey's Anatomy is just all kinds of heartbreaking, especially after we learn about Izzie's cancer diagnosis. Meredith and Derek decide to donate their wedding to Izzie. During the ceremony, Alex, after talking with a graduating valedictorian, tells his wife-to-be that today's the day his life begins. Sure, he copies a bit of his patient's speech, but the moment, when coupled with Ingrid Michaelson's emotional "Turn to Stone," is priceless.