The Cast of Netflix's Maniac Has Us Crazy-Excited For Its Premiere

La La Land actress Emma Stone will appear in the show as Annie Landsberg, who participates in a mysterious pharmaceutical trial in the hope of becoming less fixated on her broken relationships with her mother and sister.

The Wolf of Wall Street actor Jonah Hill will play Owen Milgrim, the son of wealthy New York industrialists, who has struggled his whole life with potential schizophrenia and who also participates in the trial.

Justin Theroux, who played Kevin Garvey in HBO's The Leftovers, is set to play the villainous Dr. James K. Mantleray, the scientist in charge of the drug trial and the series' primary antagonist.

Best known for playing robot Kyoto in Alex Garland's Ex Machina, Sonoya Mizuno will take on the role of Dr. Fujita, the empathetic assistant of the ruthless Dr. Mantleray.

The legendary Sally Field, who has starred in films such as Mrs. Doubtfire and Steel Magnolias, will play Dr. Greta Mantleray, boss of Dr. James K. Mantleray and the head of Neberdine Pharmaceutical and Biotech.

Julia Garner, who plays Ruth Langmore in the Netflix original series Ozark, will appear in the show as Ellie, though it's not yet clear what role her character will play.

Girls actress Jemima Kirke will also have a recurring role in the upcoming series, though it hasn't been revealed who she will play.