While we don't know who will be involved in any of these, TV Insider claims season two of Virgin River will include an engagement, a heartbreak, and a murder.
It feels too obvious for the engagement to be Mel and Jack so maybe it's Preacher or someone else. We're hoping the murder isn't Paige, but the cliffhanger at the end of the first season feels like her future is uncertain. In the books, though, Paige's ex-husband ends up behind bars and she ends up OK, so that may happen here as well.
As for heartbreak, well, that could be anyone.