In Roseanne's case, she reached her highest weight of 350 pounds just as the sitcom ended in 1997 — she then took serious measures to get in shape in 1998, when she underwent gastric bypass surgery. Since the surgery, she's had some "nips and tucks," that she discussed with WebMD.
This weight loss procedure allowed Roseanne to lose 100 pounds. But losing weight and keeping weight off are two completely different battles! The 65-year-old's trick to maintaining that dramatic weight loss isn't all that revolutionary: "Eat less and move more."