"I recommend the SkinMedica Age Defence Retinol Complex 0.5 ($78) because it has been studied head-to-head with prescription tretinoin, showing comparable efficacy in improving skin texture and tone. But the SkinMedica retinol is better tolerated by patients than prescription tretinoin, and causes less irritation, redness, stinging and dryness." — dermatologist Allison Arthur, MD, FAAD