"The Exuviance HA100 Micro-Filler ($88) has the most science behind it," said dermatologist Anne Marie McNeill, MD, PhD. "It reliably results in smoother, more hydrated-looking skin where the patches are applied. The patches are 100 percent hyaluronic acid, so they are very safe. We all naturally have hyaluronic acid in our skin. Fine lines, wrinkles, and crow's feet will all be less visible after treatment. Although these changes are not permanent, they are quite noticeable and impressive, as long as you continue using the product."