Skinceuticals Custom D.O.S.E Serum ($195) is an in-office system that blends together effective ingredients to help you achieve all your skin goals in just one bottle. A dermatologist will have you fill out a very specific questionnaire to get down to the nitty gritty of your concern (for example, if your skin doesn't respond well to retinol, you'll be able to specify that). Then, you'll watch as a heavy-duty machine dispenses and shakes up the ingredients to create your custom formula. Click here to see if this is available in your dermatologist's office.