Megan grew up in a neighbourhood referred to as "Dead End" in the South Park area of Houston, which was home to the hip-hop collective known as the Screwed Up Click. Megan's own mother, Holly Thomas, was a part of that collective, rapping and releasing music from 2001 to 2007 under the name Holly-Wood. One of her biggest hits was a single dedicated to DJ Screw, the leader of the Screwed Up Click, and her mom served as a major inspiration for Megan's own career. "I've been writing since I was maybe seven," she told Rolling Stone in March 2019. "I was kind of shy about telling people that I could rap for the longest."
Only two weeks after losing her great-grandmother in March 2019, Megan's mom (who also served as her manager), Holly, passed away at 47 after a long battle with a cancerous brain tumor. Rather than taking time off to mourn, the artist pushed herself to keep performing and promoting her first album, Fever, because she knew that's what her mom would have wanted. "No matter what I'm going through, I still want to keep going," she told The FADER in May 2019. "Just to show people you can still be strong and you can still face your everyday life. Even when everything coming down on you. I didn't cancel none of my shows 'cause I just knew — I know — how my momma is, and I know she wouldn't want me to stop."