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March 2011: Justin Timberlake and Jessica Biel Split Up

Four years into their relationship, the pair broke up in March 2011. Despite appearing close just months prior, the couple made the mutual decision to call it quits, as reported by People. A rep for the couple addressed their breakup and released a statement, which read, "Addressing the media speculation regarding Jessica Biel and Justin Timberlake's relationship, we are confirming that they mutually have decided to part ways. The two remain friends and continue to hold the highest level of love and respect for each other."