In season eight's penultimate episode, Daryl hatches a plan with Rosita to capture Eugene in an effort to deny the Saviors access to the production of additional ammo. The plan goes horribly awry when Eugene masterminds his escape by vomiting on Rosita and hiding from Daryl under the ashes of burned bodies. While his tactics appear cowardly, they point to a shift in Eugene's thinking that may have disastrous repercussions for Daryl.
Upon Eugene's return to the Saviors, he not only redoubles his efforts to crank out bullets but also expresses his determination to seek vengeance on the Alexandrians and the people of the Hilltop.
In AMC's special sneak peak of the finale, we see a hardened Eugene standby while Negan shoots a few of the newly minted rounds. Their conversation eventually settles on the pending battle, and Negan asks if the destruction of his former companions is something he really wants to see. Eugene replies, "More than need to see."
We can't help but think the cryptic reply relates directly to Daryl and Rosita — and since Eugene has already gotten the best of them once, odds are he's smart enough to do it again.
Verdict: Daryl dies.