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Season 2, Episode 5: Meredith Asks Derek to Pick Her

Ah, yes, this is perhaps one of the most iconic lines in the show's history of heart-wrenching monologues. At this point, Meredith's more than slightly annoyed that Derek hasn't signed his divorce papers yet. But she loves him. So, of course, she tells him in a heartfelt speech where she lays out all of her feelings on the table, even throwing in a Say Anything reference.

Image Source: ABC