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Season 1, Episode 2: No One Knows What They're Doing

Ah, yes, this moment is iconic in Grey's lore, illustrating how misery makes for good company. All the interns are more or less beat from saving lives or getting scut work. George asks the crew, "Who here feels like they have no idea what they're doing?" Everyone but Alex raises their hand. Don't worry — Alex will come around sooner or later.

Image Source: ABC