Dr. James K. Mantleray (Theroux), the inventor of the "miracle cure," claims he can fix any ailment of the mind, from heartbreak to psychosis. To prove it, he hosts a three-day trial with 10 strangers. This group includes Annie Landsberg (Stone) and Owen Milgrim (Hill). We know that Annie has major relationship issues with her mom and her sister. Owen comes from big-time New York City wealth, and he has a questionable diagnosis of schizophrenia.