The A Million Little Things cast is full of familiar faces to TV fans. The series stars Grimm's David Giuntoli as Eddie, Ron Livingston as Jon, Romany Malco as Rome, Allison Miller as Maggie, Christina Moses as Regina, Christina Ochoa as Ashley, Psych's James Roday as Gary, Hawaii Five-O's Grace Park as Katherine, Stephanie Szostak as Delilah, and Lizzy Greene as Sophie. Each member of the group is dealing with their own issues. Roday's Gary is worried his cancer is coming back, while the trailer reveals that Malco's Rome is struggling with depression. Add in marital and work issues, and it's clear that this capable cast is going to have lots of meaty material to work with.