No, it's not about Sherlock Holmes's wife. Brad Ricca's Mrs. Sherlock Holmes covers the 1917 missing-girl case that launched the career of Grace Humiston, the famous female detective whose talents earned her the moniker of the title. When an 18-year-old socialite goes missing in New York City, Grace and her partner tackle the case, despite pushback from the "real" police and an unending string of false leads and double-crossing witnesses.