The first book in Jeff VanderMeer's Southern Reach trilogy, Annihilation, got the big-screen treatment in 2018. The sci-fi novel's adaptation stars Natalie Portman, Gina Rodriguez, and Tessa Thompson as scientists sent on a dangerous, top-secret expedition to a location where the laws of nature don't necessarily apply. As the new environment threatens to literally tear them apart, Portman's character attempts to solve a mystery involving her husband (Oscar Isaac), who went on a similar mission months earlier and came back not-quite himself.