Actress, director, and screenwriter Lake Bell — who has appeared in rom-coms such as Over Her Dead Body, What Happens in Vegas, It's Complicated, and No Strings Attached (and has no relation to Shepard's wife Kristen Bell) — costars as Rio, Mike's wife. Bell co-created and co-wrote Bless This Mess with Elizabeth Meriwether, and she will also serve as an executive producer on the series.