Liz is the second Shepherd sister we meet and seemingly the most eager to help her siblings. She appears in season nine when Derek needs one of his sisters to donate a nerve to fix his hand. Liz ends up donating several nerves and, in her appreciation, Meredith shows her an ultrasound, revealing that Meredith's pregnant with Derek's baby.
Liz is played by actress Neve Campbell, best-known for her roles in Party of Five and the Scream movies.