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Slide 10 of 12

Derek Shepherd

Episode: Season 11, Episode 21

What happens: McDreamy's unexpected death took us a few seasons to heal from. Derek and Meredith's once-ideal relationship slips in season 11 when he takes a job in DC. They manage to patch things up by the last couple of episodes that season, but of course, things are too good to be true. Derek gets hit by a car after helping a group of people on the road. Because he ends up at a subpar hospital, he becomes brain-dead. Meredith lets him go soon after. We're still not OK, but we're glad Meredith eventually grows from the experience and finds peace (and DeLuca).