He'll Become Public Enemy Number 1
Public Enemy Number One is a title well-known to the web-slinger of New York City — just not this one. As wild as Peter's adventures have been in the MCU, he's never had to face the wrath of the public like his previous iterations, especially since he didn't have the editor in chief of the Daily Bugle to contend with. Despite all his good deeds, Peter will definitely be under some heat since Mysterio's recording points the dirty finger at him for being behind the destruction of most of Central London.
Next time we see Peter, he's probably going to be persona non grata as he and his circle of friends rush to clear his name. It doesn't help that Mysterio's video also reveals the fact that Peter (via Tony Stark) has possession of some highly intelligent, and dangerously lethal, drone tech. Tony's been in hot water with the government for his tech before, the knowledge that he left something like EDITH in the hands of a teenager is not going to sit well with anyone.
Call it a hunch, but Peter will probably be going through a really tough time with having his identity exposed, especially since it puts Aunt May, MJ, and Ned in direct line of danger. His ability to don the Spidey-Suit and save the day will be severely hampered. Tony pulled off his public Iron Man persona because he was so honestly in-your-face about it all. Peter is just a teen who mostly wants to live his life, with saving the world as a side hustle. The transition definitely won't be easy.