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Season 1, Episode 1: "A Hard Day's Night"

The pilot explores so many different facets of Meredith's life — her family, career, and romance. Yet it's still cheerful and playful, with none of that signature Grey's Anatomy emotional trauma blasting at us with full force. You just can't help but feel something when hearing "Portions For Foxes" play while Meredith scuttles to her first day of work as an intern right after an awkward and sexy encounter with Derek post-one-night-stand.