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Glee

Much like Nip/Tuck, Glee started out strong but faded in quality as cast shake-ups and a shift to too many culture-of-the-moment song choices. Still, at its best, it's one of Murphy's best: jaw-dropping satire, messy characters, and a kind heart buried way deep down. Plus, its cultural impact is probably the biggest out of anything else Murphy has written.

Image Source: Everett Collection