Marked by Ira Glass's distinct voice, This American Life has been on for literally decades, starting first as a radio show then branching into the podcast universe later on. Over the years, it's been widely influential, single episodes inspiring whole movies and TV series. This American Life also produced its own TV series based on the radio program back in the early aughts (2007-2009). While the series is long gone (asked to be taken off by Glass and other creators because of TV's demanding schedule), you can catch new podcast episodes of This American Life every week.
Listen to This American Life now.