When Kimmy chases the Reverend to West Virginia, she and Titus wind up at a gas station attended by Johnny Knoxville. He provides them with the general direction that the Reverend ran off in but quickly leaves to move his ankle bracelet around, so the cops think he's still at home. Kimmy and Titus are surprised to discover that he's left his baby in the shop and are given the choice to stay with the baby or abandon her to run after the Reverend.
It goes against her nature, but if you choose to have the duo abandon the baby to chase the Reverend, it doesn't end well. Even if you read the book and Kimmy can use it for guidance, they won't arrive in time to stop him from driving off with the women. Even worse, you've made Kimmy act in a way that's opposite her nature, and Mikey scolds you for it. "Kimmy is a good person, and you're not making good choices for her," he says. "That just got dark, like that show Spooky Mirror."