Returning cast members include Neve Campbell, Courteney Cox, David Arquette, and Marley Shelton, who made her first franchise appearance in the fourth instalment. Scream will also feature several new cast members, including Jack Quaid, Melissa Barrera, Jenna Ortega, Dylan Minnette, Jasmin Savoy Brown, and more.
Campbell, who portrays the film's central Sidney Prescott, was initially hesitant about continuing the franchise, but she was ultimately swayed by a heartfelt letter from Gillett and Bettinelli-Olpin. "The two directors wrote me a very touching letter about Wes Craven and how he was such an inspiration to them and how they really want to honour him, and that meant a great, great deal to me," Campbell said in May.
Gillett, meanwhile, spoke highly of the Scream cast when he said, "The experience that we've had with the cast — both legacy characters and new cast members — I don't think it comes around maybe but once in a career."