Of all the women on this list, Debra Messing is the only one that's actively thrown her name into the ring. On Jan. 12, she retweeted a fan's comment saying that Messing was "unavailable" with a comment of her own, "Oh no, I'm available." She also liked numerous tweets with fans calling for her to be cast in the part, even responding to those who said she wouldn't do it, tweeting: "Ummmmmm, I changed my mind." Beyond Twitter being on board with Messing's casting, Will & Grace had an entire I Love Lucy tribute episode called "We Love Lucy." On the episode, Messing re-enacted Ball's iconic Vitameatavegamin commercial.