After skipping an episode, since episode four took place mostly in the outside, real world, the commercial returned for episode five, which imitates an '80s sitcom. This commercial is pretty easy to interpret. The "Lagos" paper towels are named after the city where Wanda tried to contain an explosion and instead accidentally redirected it towards a building, where civilians were killed.
"For when you make a mess you didn't mean to," the slogan goes, which seems to accurately reflect Wanda's reaction to the Lagos accident: a devastating mess that happened without her intending any harm. During the episode where this commercial airs, there are a few hints that Wanda is confused about parts of "her" sitcom: she mentions not knowing how the whole thing even started, and she's shocked when a doorbell rings and reveals a version of her late brother on the other side. Could this commercial be suggesting that Wanda isn't as much "at fault" for what's happening as the other characters currently believe?