Taylour Paige stars as the titular Zola, while Riley Keough plays a sex worker named Stefani. The film also features Nicholas Braun as Stefani's boyfriend, Derrek; Colman Domingo as Stefani's pimp, X; Ari'el Stachel as Sean; Jason Mitchell as Dion; Nelcie Souffrant as Gail; and Ts Madison as Hollywood.