What Happened to Doc Ock in Spider-Man 2?
Arguably the most iconic of the on-screen Spidey villains so far, Doc Ock made his first appearance in Spider-Man 2. Dr. Otto Octavius actually starts as an ally and mentor to Peter Parker, encourageing him in science. However, when a lab accident fuses robotic tentacles to his body, their artificial intelligence turns him into a man obsessed with completing his research at all costs. Spider-Man tries to stop him as his research becomes more and more dangerous, and in the end, Octavius overcomes the tentacles' power and puts an end to his own villainy.
Why is the Doc Ock in Spider-Man: No Way Home?
Judging by the trailers for No Way Home, it certainly looks like Doc Ock will have a particularly large role to play in the story. The second trailer shows him seemingly captured by Spider-Man, Doctor Strange, and their friends, and he almost immediately realises, when he's fighting this Spider-Man, that this isn't the same hero he battled before.