Marvel has been branching into the multiverse a lot lately. Between Loki, No Way Home, and Doctor Strange in the Multiverse of Madness, that seems to be the theme of the next major phase of the entire Marvel universe. So it only makes sense that, having introduced the other big-screen versions of Spider-Man, the next logical step would be bringing Miles Morales out of the animated universe and into the live-action one. Given that Tom Holland has said he doesn't want to play Spider-Man too long, it would make sense for him to start passing the Spider-Man baton along, and Miles is the likeliest candidate.
No Way Home seemed to wink at this possibility in one notable scene. After being saved and cured by the Spider-Men, Max Dillon (aka Electro) finally meets his universe's Peter Parker, played by Andrew Garfield, unmasked. He half-jokes that, given Spider-Man's origins in Queens and his penchant for helping ordinary people, he expected Spider-Man to be Black. Max and Peter then agree that maybe somewhere or in some universe, there's a Black Spider-Man — like Miles, perhaps?