JoJo posted on Instagram back in 2016 that "Save My Soul" was inspired by her late father's death after complications from drug addiction. "I'm not mad at my dad. I love him and I'm sad. He is my greatest heartbreak. This song, which had always been personal to me, takes on even deeper meaning now. 'I try to run but it hurts every time I try . . . Lord I try and I can't say no.' Makes me think of the universal struggle of seeking victory over the feeling of powerlessness to a situation, a lover, a drug," she wrote. "Losing my father at the end of last year and knowing the propensity for addiction of all kinds that runs deep in my blood from both sides makes it next-level important for me to LIVE — not just be alive, but THRIVE in his honour. I can do this. And so can you."