My pain tolerance falls somewhere between a newborn baby's and Batman's exoskeleton suit, and I'd rank Botox at about a 3. You'll feel a slight prick at the injection sight, but it's hardly anything you'll need Demerol for. As with most times you're getting poked with a needle, the worst part is mostly the anticipation of it all. That said, if you're especially sensitive to pain, ask your dermatologist to apply a topical anesthetic cream 20 minutes before to numb the area. You won't feel a thing.