Reese and Jennifer Aniston first worked together on the set of Friends in 2000, when Reese made a guest appearance as Rachel Green's self-absorbed little sister Jill. When Reese got flustered while filming and flubbed her lines, Jen was there to comfort her with a hug and kind words. "She was so sweet to me," Reese recalled during an October 2019 conversation with Natalie Portman for Harper's Bazaar, later adding, "We've been friends ever since." The two are now executive producers and costars on Apple TV+'s The Morning Show, and Jen still lovingly refers to Reese as her "little sister."