Starring in another history-making film adaptation of a book, Winfrey's role as Mrs. Which is the cherry on top of this already superempowering film. Not only does it include the squad of our dreams (Oprah, Reese Witherspoon, Mindy Kaling), but it is also a huge win for women in film — Ava DuVernay is the first women of color to direct a motion picture with a budget of over $100 million. This is also a reunion for DuVernay and Winfrey, who first teamed up for Selma.