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Season 2, Episode 5: "Bring the Pain"

This episode definitely laid the cheese on thick, but we're not even mad because the drama is insatiable. As they're searching for a shaman for their patient, Meredith and Derek find themselves at a crossroads in their relationship. Addison, Derek's estranged wife, is settling down at Seattle Grace. Derek hasn't signed divorce papers yet, unsure of what to do.

After they finish a surgery, Meredith gives Derek the disarmingly sweet "pick me, choose me, love me" speech and tells him to meet her at Joe's after work. Meredith gets terribly drunk by the end of the episode, and it looks like Derek's a no-show. While it's definitely sad, the drama is relatively lightweight compared to what's to come in their relationship.