Veneno tells the story of the real-life Spanish LGBTQ+ icon Cristina "La Veneno" Ortiz. To bring the legendary trans performer to life on screen, three talented actresses — Daniela Santiago, Jedet, and Isabel Torres — portray La Veneno throughout different points of her adult life. The show has something that everyone can connect to and contains plenty of emotionally tender moments to balance out La Veneno's larger-than-life personality.