In Peter's fight to defeat the Green Goblin, May gets injured. She continues to assure her nephew that he did the right thing by trying to help the villains. The wound is more severe than what they initially thought, and it's clear May is going to die. As she's dying, she says, "With great power, comes great responsibility." Spider-Man fans will recall, that quote is something Uncle Ben told Maguire and Garfield's Peter when he died. Cue the ugly cry!