Obviously, each universe in the multiverse has a bit of a different story. Each Peter Parker has a slightly different family and friends. While Tom Holland's Peter has Ned as a best friend, the others don't. In fact, Tobey Maguire's Peter tells Ned in this movie that his best friend betrayed him and died in his arms, his best friend being Harry Osborn (James Franco), who became Green Goblin after his father, Norman, died. Ned is visibly shaken by this statement and tells his Peter that he'll never turn into a supervillain and try to kill him.