Talk about being at the wrong place at the wrong time. Sean Jones was just going for a joy ride on his motocross when he accidentally witnessed mobster Eddie Kim take the life of a prosecutor who was on the cusp of putting him behind bars, which Eddie solved with a deadly blow. Now Sean has unintentionally found himself playing the role of primary witness in Eddie's trial. Before he knows it, he's being escorted by FBI agent Neville Flynn (Samuel L. Jackson) on a red-eye flight to Los Angeles. At the push of a button, things take a turbulent turn when Eddie's hitman onboard the aircraft releases a time-operated crate of deadly venomous snakes.