We'll tell it to you straight: The SkinMedica TNS Advanced+ Serum ($295) costs a pretty penny — and we've shed a tear for all 29,500 of them every time we run out. It harnesses a magical power to transform skin in just a month's time, taking it from dull and lifeless (thanks to limited outside activity) to bright and supple (thanks to its proprietary growth factor blend). If you are after a heavy hitter that really works and have the means, this will become your go-to.