With a powerful dose of 0.3 percent retinol in the formula, the Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol (£56) helps reduce the early signs of ageing like wrinkles and fine lines, and smooth out uneven texture overnight. To make the active ingredients more tolerable, the formula also contains hyaluronic acid, mango seed butter, and squalene for hydration. And as it says right on the packaging, this cream should only be used at night — and followed up by SPF in the morning.