Since My Girl, Dunne — now 63 — has appeared in the movies Quiz Show, I Like It Like That, and Dallas Buyers Club. He has also made guests appearances on the small screen, with roles in Frasier, Alias, Law and Order, and House of Lies. Though it only lasted one season, Dunne also played Tony Mink in the TNT comedy Trust Me.
Dunne has earned several producing and directing credits, and was nominated for an Academy Award for Duke of Groove, which he directed and cowrote. Other production credits include Baby It's You, After Hours, Running on Empty, and Game 6. He has also directed five feature films, including Addicted to Love and Practical Magic. Though he and his wife of six years, actress Carey Lowell, divorced in 1995, Dunne remarried in 2009 to Australian stylist Anna Bingemann. He and Carey have one daughter together, actress Hannah Dunne.