Popsugar Entertainment Twitter Reactions Holly Marie Combs and Alyssa Milano on Grey's Anatomy A Charmed Reunion Is Finally Happening, but It's Going Down on Grey's Anatomy 17 September 2019 by Mekishana Pierre Image Source: ABC Grey Sloan Memorial is about to get Charmed with a Halliwell reunion going down in season 16. That's right, Alyssa Milano and Holly Marie Combs will portray sisters in an upcoming episode of Grey's Anatomy, slated to air on Oct. 10. Though they won't be reprising their Charmed characters — Milano and Combs portrayed Phoebe and Piper Halliwell, respectively — their guest appearance will reunite them with Krista Vernoff and Andy Reaser, who were writers on Charmed and currently serve as executive producers on Grey's Anatomy. The two will play sisters who arrive at Grey Sloan after their other sister is admitted following a fall at a construction site (sounds pretty similar to another sister's demise). When she becomes brain dead, Combs and Milano must decide whether to keep her alive. So, it's a totally chill episode for the two to reunite! ABC shared a photo from the episode on the show's Twitter account on Monday, showing the two actors in character at Grey Sloan. "We're excited to have the charmed ones @milano_alyssa and @thehmc guest-starring on #GreysAnatomy! #CastFromThePast," they captioned the post. They obviously aren't the only ones excited: fans quickly stormed Twitter with their delight over the guest appearances. Check out their excitement ahead and get ready for Grey's Anatomy to return on Sept. 26! Related: You Heard Right: Grey's Anatomy Season 16 Will Include a Major Time Jump Grey's Anatomy Announcement Tweet We’re excited to have the charmed ones @Alyssa_Milano and @H_Combs guest-starring on #GreysAnatomy! #CastFromThePast pic.twitter.com/CksxD9NRgE— Greys Anatomy (@GreysABC) September 16, 2019 1 / 13 Holly Marie Combs's Responses #castfromthepast with all the feels and I mean ALLLLLLLLLLLLLLLLL. https://t.co/W3qNg3QnGv— Holly Marie Combs (@H_Combs) September 16, 2019 2 / 13 Reunited. And we couldn’t be happier. kristavernoff @andyreaser well... there were some tears.... just some. @greysabc https://t.co/NJI8flKpmk— Holly Marie Combs (@H_Combs) September 16, 2019 3 / 13 Fan Reactions to the Reunion ALYSSA MILANO AND HOLLY MARIE COMBS ARE GONNA GUEST STAR ON GREY’S ANATOMY IM GOING TO SCREEAAAAAAAAAAAAAAAM pic.twitter.com/oAGIK4RamR— 𝓃𝑒𝓂𝑜 (@thegoodlesbians) September 16, 2019 4 / 13 15 WHOLE YEARS of watching #GreysAnatomy and in the 16th we get Alyssa Milano and Holly Marie Combs back TOGETHER again. AS SISTERS. I- pic.twitter.com/y50PpFw91p— ΝiKi🌛 (@Phoebe1_) September 16, 2019 5 / 13 “Combs and Milano play the sisters of a patient who is brain dead after falling at a construction site.” Hmm it has my thinking 🤔. pic.twitter.com/32atlLnbDo— Ty Wright (@TyWrigh69036735) September 17, 2019 6 / 13 THE CHARMED ONES? pic.twitter.com/N4GUlHIS1l— ريان (@ryantheWarlock) September 16, 2019 7 / 13 Holly & Alyssa visiting their sister in hospital on Charmed 1998Holly & Alyssa [presumably] visiting their sister in hospital on Greys anatomy 2019 #Charmed #Greysanatomy pic.twitter.com/RBfeWoKnbR— Charmed fan (@Charmedfan2720) September 17, 2019 8 / 13 Love this xx #charmed #CharmedReunion pic.twitter.com/nTSld9XhAi— Gem hudson Marriott 🥀🇬🇧🌈 (@xgemsx85) September 17, 2019 9 / 13 A Charmed and Grey’s Anatomy collaboration? pic.twitter.com/wVTvF32A9n— dick van d slur (@WhorticiaA) September 17, 2019 10 / 13 I am so happy you and @Alyssa_Milano are working together again and as sisters 😊😍. I was really hoping it was charmed related but its so good to have you both back ❤ I hope it's more then one episode 🙏🏾 I watched Grey's anatomy never liked it but that could change now!.— Charlene Lewis (@char_charmed) September 16, 2019 11 / 13 I’m happy about this @H_Combs & @Alyssa_Milano news I love greys anatomy, I’m just happy to see them on screen together again as sisters even if it’s not In a charmed way . REAL FANS WOULD BE EXCITED FOR THEM REGARDLESS pic.twitter.com/OxsTvuCjFK— Your True Sushi Queen (@KillahSushi) September 16, 2019 12 / 13 Cultural impact 2019: █ █ █ █ __ Alyssa Milano Anything elseHolly Marie Combs on #GreysAnatomy— Charmed_Reunion (@Charmed_Reunion) September 17, 2019 13 / 13 Twitter ReactionsHolly Marie CombsCharmedNostalgiaAlyssa MilanoGrey's AnatomyTV