Alex Announces to Izzie That This Is the Day His Life Begins
Episode: Season 5, Episode 22
What happens: Alex draws inspiration from a car accident victim who was just about to give her college valedictorian speech. He incorporates her lines into his wedding vows. He sweetly announces to Izzie that this is the day his life begins. We know, we know, Alex and Izzie don't last, but that doesn't take away from the sweetness of the moment.