A whirlwind of major life changes hit Owen lately. The trauma surgeon learns that his sister Megan is still alive, and throughout her stay at Grey Sloan, she makes him realise that he and Amelia are not working out. Though Owen and Amelia split up, they have occasional hookups.
The trauma doctor later flies to Germany and shares a passionate encounter with Teddy. The moment, however, is short-lived, and ends with the cardiothoracic surgeon asking him to leave upon learning that he had been with Amelia shortly before. Owen's relationship with Amelia continues when he takes in a foster child named Leo. Amelia lends him a helping hand as she herself takes in Betty, Leo's teenage birth mother.