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Slide 22 of 28

Lisa Kudrow as Roz Doyle on "Frasier"

Another "Friends" alum similarly missed out on an iconic TV role. Lisa Kudrow was originally cast as Roz Doyle on "Frasier", but during rehearsals for the pilot episode, producers felt Kudrow wasn't playing Roz the way they'd imagined. As "Frasier" cowriter Peter Casey explained in an essay for Ken Levine's blog in December 2006, "By the third day of rehearsals it was becoming apparent to Jim Burrows, Kelsey [Grammer], and the three of us that things weren't going so well with Lisa as Roz. Although she remained funny in her quirky way, we found that each day we were re-writing the character less strong because Lisa just didn't play forceful." Peri Gilpin replaced Kudrow, and Kudrow was cast on "Friends" soon after.