Ghostface Terrorises Jenna Ortega, Melissa Barrera, and Courteney Cox in the "Scream 6" Trailer

In July 2022, Deadline reported that Samara Weaving and Tony Revolori are joining the cast. Weaving is no stranger to horror, having previously starred in 2019's "Ready or Not." Revolori plays Flash Thompson in Tom Holland's Spider-Man films. Other newcomers to the cast include "She-Hulk"'s Josh Segarra.

A month earlier in June, Deadline reported that Neve Campbell, who appeared in all five previous Scream films as Sidney Prescott, would not be returning for "Scream 6." "Sadly I won't be making the next Scream film," she said, according to Deadline, citing salary issues. Still, some major stars are set to come back.

In May 2022, The Hollywood Reporter confirmed that Hayden Panettiere, one of the stars of 2011's "Scream 4," will return as her character Kirby Reed. Back in 2011, Panettiere played a horror-obsessed high school student who narrowly managed to evade Ghostface. Also returning is Courteney Cox as Gale Weathers. Dermot Mulroney also joins the cast as a police officer who tries to help them.

The film will also see the return of the principal cast from 2022's "Scream," which includes Mason Gooding (Chad), Jenna Ortega (Tara), Melissa Barrera (Sam), and Jasmin Savoy Brown (Mindy).

Paramount describes the plot this way: "Following the latest Ghostface killings, the four survivors leave Woodsboro behind and start a fresh chapter." In the trailers, we see Tara, Sam, and their friends trying to forge a new life in New York City, but Ghostface has followed. In New York, Gale Weathers and Kirby Reed try to help them take Ghostface down for good.

"Scream 6" will hit theatres on 10 March.