Following her split from René Elizondo Jr., Jackson was in a long-term relationship with rapper Jermaine Dupri from 2002-2009. One year after her split with Dupri, Jackson met and started dating businessman Wissam Al Mana in 2010. In 2012, the pair married, and in January 2017, Jackson had her first child with him, Eissa.
Shortly after the birth of their son, the couple separated and filed for divorce, citing cultural differences. At the time, a source close to Jackson told "People," "The cultural differences between her and Wissam became even more obvious [after Eissa arrived]. They come from very different worlds." While the pair separated in 2017, their divorce has not been finalized yet.