Plot: Season 12 is all about Meredith's life after Derek. This might be a controversial stance, but Derek's death is possibly what the show needed to freshen things up around Grey Sloan. We get to see Meredith focus hard on her career and develop her relationship with Alex, her sisters, and even Penny, the intern who was on-call when Derek died. There's also solid secondary plots as well, especially April and Jackson's marriage drama after her return from Jordan.
Ending: Season 12's finale isn't all that sad, but we're still heartbroken over Callie's departure to New York after an intense custody trial with Arizona. Ben saves the day by assisting April's delivery before help arrives. Amelia, after getting a bit of cold feet, finally marries Owen. All is well, except for um, Alex punching the living lights out of DeLuca.
Weepiness: It's not a particularly weepy season, but you're bound to get teary-eyed here and there thinking about how Meredith is grieving.