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Season 2, Episode 1: "Raindrops Keep Falling on My Head"

While the show's pilot established their friendship, this episode further tightens Meredith and Cristina's relationship. Cristina admits that she's pregnant and that she put Mer down as her person on her termination appointment. It's the first time that we see Cristina vulnerable around anyone, and wow did it punch us in the feelings. Grey's Anatomy might be known for its steamy hookups and grand romances, but it also features the best ride-or-die friendship moments on primetime.

Image Source: ABC via Giphy